MALADIE DE CHURG ET STRAUSS PDF

Le syndrome de Churg et Strauss est une vascularite associée à un asthme et une éosinophilie. L’atteinte respiratoire est marquée par un asthme tardif. Eosinophilic granulomatosis with polyangiitis (EGPA)—or, as it was traditionally termed, Churg-Strauss syndrome—is a rare systemic. Eosinophilic granulomatosis with polyangiitis (EGPA), also known as Churg– Strauss syndrome (CSS) or allergic granulomatosis, is an extremely rare.

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L’atteinte cardiaque, souvent silencieuse, domine le pronostic. Churg-Strauss syndrome is a vasculitis associated with asthma and eosinophilia.

Respiratory involvement is marked by generally severe and often steroid-dependent late-onset asthma associated with allergic rhinitis and sometimes nasal polyposis and recurrent sinusitis. Asthma generally precedes the systemic vasculitis by a few years. General signs, eosinophilic gastroenteritis, peripheral multiplex neuropathy, cutaneous vasculitis, nephropathy, or arthromyalgia, predominate.

Cardiac involvement is often silent but of severe prognosis. The chest X-ray usually shows irregularly delimited and sometimes labile infiltrates.

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Eosinophilic Granulomatosis with Polyangiitis (EGPA; formerly Churg-Strauss Syndrome)

Perinuclear antineutrophil cytoplasmic autoantibodies ANCA are found in two-thirds of the patients and strongly suggest the diagnosis. Histological confirmation is usually necessary nerve and muscle biopsyshowing small-vessel dhurg vasculitis, tissue infiltration with eosinophils, and eosinophilic granulomas. Treatment includes corticosteroids, which should be associated with immunosuppressive agents cyclophosphamide in severe cases.

EosinophiliaVasculitisAsthmaChurg-Strauss syndrome.

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Eosinophilic granulomatosis with polyangiitis – Wikipedia

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