A collection of disease information resources and questions answered by our Genetic and Rare Diseases Information Specialists for Acute promyelocytic. Trasplante de células madre. Tratamiento para la leucemia promielocítica aguda. Tratamiento para la leucemia monocítica aguda. Tratamiento para la AML en. acute promyelocytic leucemia presenting during pregnancy. Clin Leukemia ; Cardonick E, Iacobucci A. Use of chemotherapy during.
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Treatment of acute promyelocytic leukemia: A single institution experience. Correspondence and reprint request: Recibido el 4 de noviembre de Aceptado el 6 de abril de There were no instances of the ATRA syndrome.
The treatment employed differs from others in: Oral prednisone is used prophylactically, ATRA is given on an outpatient basis and adriamycin is used instead of other anthracyclines.
All transretinoic acid ATRA. ATRA was given until reaching a complete hematological remission, as defined by usual criteria.
Fourteen patients were followed for more than 30 days and therefore, prospectively accrued in this study; they were observed for periods ranging from 67 to 4, days median 1, The molecular remission was achieved after the administration of ATRA in five patients, whereas in the remaining eight, chemotherapy CT was required to finally achieve it.
Three patients received an autologous peripheral blood stem cell transplantation 4, 6, 9,19 after achieving the molecular remission, in two instances during the first CR and in one, during the second CR vide supra. Substantial progress has occurred in the treatment of APL because of improved understanding of the pathophysiology of the disease and identification of a molecular target.
Results from several randomized studies have evaluated various regimens of ATRA alone or in combination with CT to determine optimal induction therapy in patients with newly diagnosed APL. The roles of both consolidation therapy with CT including anthracyclines as well as the maintenance therapy with ATRA, mercaptopurine and methotrexate have been also well defined. The method which we have previously published and employed to treat patients with PML, 13 includes prednisone during the first three weeks of treatment; this addition has resulted in the eradication of the ATRA syndrome, which in our hands is no longer a problem; prospective studies to define the definite role of steroids in this setting are needed.
In addition, we elected to deliver ATRA fully on an outpatient basis, thus diminishing hospitalization costs. Eur J Haematol ; Reverse transcription polymerase chain reaction for the rearranged retinoic acid receptor alpha clarifies diagnosis and detects minimal residual disease in acute promyelocytic leukemia.
Clin Lab Haematol ; From genetics to treatment. Am J Hematol ; Promyelocytic leukemia in Mexican mestizos. High frequency of acute promyelocyitic leukemia in Mexican Mestizos.
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Tratamiento de la leucemia promielocítica aguda: Experiencia de una sola institución
Toxicity and survival in de novo patients. Blood ; 84 Suppl. Flow cytometry in the clinical laboratory.
Principles, applications promielociticaa problems. Ann Biol Clin ; Report of the first Latin American consensus conference for flow cytometric immunophenotyping of leukemia.
Cytometry Communications in Clinical Cytometry ; Outpatient supportive therapy after induction to remission therapy in adult acute myelogenous leukaemia AML is feasible: Acta Haematol ; Kaplan EL, Meier P.
Nonparametric estimations from promlelocitica observations. J Am Stat Assoc ; High frequency of acute promyelocytic leukemia among latinos with acute myeloid leukemia Letter.
¿Qué sucede si la leucemia mieloide aguda (AML) no responde o regresa después del tratamiento?
Medicin Univ ; 1: Association promielocitlca increased body mass index and a diagnosis of acute promyelocytic leukemia in patients with acute myeloid leukemia.
High frequency of acute promyelocytic leukemia in Mexican mestizos. Blood ; 90 Suppl. Cellular immunophenotypes in 97 adults with acute leukemia. More on geographic hematology: Leuk Lymphoma ; Acute promyelocytic leukemia as a paradigm for targeted therapy. Semin Hematol ; Pathogenesis and management of acute promyelocytic leukemia.
Annu Rev Med ; Vasco de Quiroga No.