INSULINORRESISTENCIA Y OBESIDAD PDF

Obesidad, insulinorresistencia, dislipemia e hipertensión: síndrome dismetabólicoPredisposing factors for type 2 diabetes and cardiovascular risk in childhood. G. Marañón. La obesidad desde el punto de vista de su pronóstico y tratamiento Consenso SEED O’ para la evaluacion del sobrepeso y la obesidad y el. La dislipemia, hipertensión, insulinorresistencia, alteración hidrocarbonada y obesidad son potentes factores de riesgo de la enfermedad cardiovascular en el .

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Adiponectina, Obesidad, Enfermedades cardiovasculares, Adipocinas. Obesity is closely associated to the metabolic syndrome, hypertension, atherosclerosis, and heart disease.

Adipose tissue works as an endocrine organ by secreting multiple immune modulatory proteins known as adipokines, which can act directly on nearby or remote organs. Adipokines seem to be the link between obesity and cardiovascular disease. Obesity leads to a greater expression of pro-inflammatory adipokines and a decrease in anti-inflammatory adipokines, conditioning chronic inflammatory state promoting complications related to obesity. Within these adipokines, the adiponectin protects against the development of ischemic heart disease insulinorresitsencia improves cardiovascular health, but its expression decrease in obese subjects.

Following a review is presented. Adiponectin, Obesity, Cardiovascular diseases, Adipokines. Adicionalmente, el TA perivascular puede secretar factores anti-inflamatorios dentro de los que se encuentra la adipocina 4142 Las tiazolidinedionas, son agentes orales para el tratamiento de pacientes con diabetes mellitus tipo 2 La pioglitazona mejora la resultante cardiovascular en pacientes con diabetes mellitus tipo 2 La grasa visceral se ha reconocido como un factor agravante en la diabetes, que se correlaciona bien con el papel del TA perivascular en la enfermedad.

Adipokine expression and secretion by canine adipocytes: Pflugers Arch – Eur J Physiol ; Diabetes Metab J ; Clin Sci Lond ; Adamczak M, Wiecek A. The adipose tissue as an endocrine organ. FGF21 attenuates pathological myocardial remodeling following myocardial infarction through the adiponectin-dependent mechanism.

Biochem Biophys Res Commun ; Trends Cardiovasc Med ; Adipose tissue remodeling and obesity.

J Clin Invest ; Aging and regional differences in fat cell progenitors – a mini-review. Dead adipocytes, detected as crown-like structures, are prevalent in visceral fat depots of genetically obese mice. J Insulinorresietencia Res ; Adipocyte death, adipose tissue remodeling, and obesity complications. Telmisartan improves insulin resistance and modulates adipose tissue macrophage polarization in high-fat-fed mice. Regulatory mechanisms for adipose tissue M1 and M2 macrophages in diet-induced obese mice.

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Alternative activation of macrophages: Annu Rev Immunol ; Macrophages, immunity, and metabolic disease. Inflammatory characteristics of distinct abdominal adipose tissue depots relate differently to metabolic risk factors for cardiovascular disease: Arteriolar function in visceral adipose tissue is impaired in human obesity. Arterioscler Thromb Vasc Biol ; Reduced oxygenation in human obese adipose tissue is associated with impaired insulin suppression of lipolysis.

J Clin Endocrinol Metab ; Increased adipose tissue oxygen tension ijsulinorresistencia obese compared with lean men is accompanied by insulin resistance, impaired adipose tissue capillarization, and inflammation.

In vivo imaging in mice reveals local cell dynamics and inflammation in obese adipose tissue. Perivascular fat in human muscle. Lancet Diabetes Endocrinol ;4: Crosstalk between perivascular adipose tissue and blood vessels.

Curr Opin Pharmacol ; Effects of obesity on perivascular adipose tissue vasorelaxant function: J Vasc Res ; Perivascular adipose tissue modulates vascular function in the human internal thoracic artery. J Thorac Cardiovasc Surg ; Role of caveolin-1 in endothelial BKCa channel regulation of vasoreactivity. Am J Physiol Cell Physiol obesidax Macrophage activation is responsible for loss of anticontractile function in inflamed perivascular fat.

Obesidxd adipocytes and perivascular adipose tissue obedidad vascular smooth muscle cell proliferation: Perivascular adipose tissue-derived visfatin is a vascular smooth muscle cell growth factor: Inflammation, metaflammation and immunometabolic disorders.

Immunometabolism of obesity and diabetes: Long-term body weight variability is associated with elevated C-reactive protein independent of current body mass index among Japanese men.

Biomarkers of endothelial dysfunction and risk of type 2 diabetes mellitus.

Effect of weight loss and lifestyle changes on vascular inflammatory markers in obese women: Subcutaneous and visceral adipose tissue gene expression of serum adipokines that predict type 2 diabetes. Obesity Silver Spring ; Pathways regulated by glucocorticoids in omental and subcutaneous human adipose tissues: Am J Physiol Endocrinol Metab ; Proinflammatory phenotype of perivascular adipocytes. Aging up-regulates expression of inflammatory mediators in mouse adipose tissue.

Gene expression profile of mouse white adipose tissue during inflammatory stress: Role of antiin flammatory adipokines in obesity-related diseases.

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Trends Endocrinol Metab ; Association of hypoadiponectinemia with impaired vasoreactivity. Syndecan-4 deficiency limits neointimal formation after vascular injury by regulating vascular smooth muscle cell proliferation and vascular progenitor cell mobilization. Adiponectin is synthesized and secreted by human and murine cardiomyocytes. Isolation and characterization of GBP28, a novel gelatin-binding protein purified from human plasma. Ruan H, Dong LQ.

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Adiponectin signaling and function in insulin target tissues. J Mol Cell Biol ;8: Sawicka K, Krasowska D. Adipokines in connective tissue diseases. Clin Exp Rheumatol ; Role of adiponectin receptors in endothelin-induced cellular hypertrophy in cultured cardiomyocytes and their expression in infarcted heart. Targeting AMP-activated protein kinase as a novel therapeutic approach for the treatment of metabolic disorders. The emerging role of adiponectin in cerebrovascular and neurodegenerative diseases.

Biochim Biophys Acta ; Novel modulator for endothelial adhesion molecules: Adiponectin as a potential biomarker of vascular disease.

ADIPONECTINA, OBESIDAD Y ENFERMEDADES CARDIOVASCULARES

Vasc Yy Risk Manag ; Adipocytederived plasma protein, adiponectin, suppresses lipid accumulation and class A scavenger receptor expression in human monocyte-derived macrophages. Horm Metab Res ; Adipocyte-derived plasma protein adiponectin acts as a platelet-derived growth factor-BB-binding protein and regulates growth factor-induced common postreceptor signal in vascular smooth muscle cell.

Plasma total and high molecular weight adiponectin levels and risk of coronary heart disease in women. Hypoadiponectinemia is an independent risk factor for hypertension. Zhang HL, Jin X. Relationship between serum adiponectin and osteoprotegerin levels and coronary heart disease severity. Genet Mol Res ; Caloric restriction stimulates revascularization in response to ischemia via adiponectin-mediated activation of endothelial nitricoxide synthase.

J Biol Chem ; Adiponectin prevents cerebral ischemic injury through endothelial nitric iinsulinorresistencia synthase dependent mechanisms. Role of adiponectin ihsulinorresistencia preventing vascular stenosis. The missing link of adipo-vascular axis. A novel mechanism for vascular insulin resistance in normotensive young SHRs: Adiponectin inhibits the production of Insulinorresistenciaa receptor 3 chemokine ligands in macrophages and reduces T-lymphocyte recruitment in atherogenesis.

Lack of association between adiponectin levels and atherosclerosis in mice.